DestroyTwitter is a compact though robust Twitter application built to run on Mac, Windows, and Linux using Adobe AIR. It consists of a series of canvases that constantly update to keep tweets up-to-date using notifications that appear when a new tweet arrives. DestroyTwitter uses a minimal amount of memory compared to its AIR-based alternatives without sacrificing functionality and performance. As a result, it can easily run in the background as an automated process.
I really like DT. It is great for a small client running on Air. It is not as feature rich as tweetdeck, does not support lists, but I really like some of the autofill features, the clean interface, and the simplified view (collapsing the columns into one). I if it could refresh more often than 30 seconds, it would become my main twitter client (a must have feature for participating in chats).
For all these reviews, it's surprising how none of them mention that DestroyTwitter has no support for lists - while it has multiple columns, you can't change what the columns are (Home, Mentions, Search, and DMs). Good maybe for many people, but since I've gotten into the habit of listing everything into lots of columns (thanks to TweetDeck), DestroyTwitter really can't do the job for me until the developer adds list support (coming in 2.2? but 2.2's been coming for a long while now).
I've tried changing to another client several times but really, DestroyTwitter has it all, it's based on AIR but it's still very light on a Mac or any computer, it has a decent set of features, canvases, autocomplete for mentions, URL shortening and a couple of more advance features, everything in a neatly designed UI, what else could you ask for?