DestroyTwitter is a compact though robust Twitter application built to run on Mac, Windows, and Linux using Adobe AIR. It consists of a series of canvases that constantly update to keep tweets up-to-date using notifications that appear when a new tweet arrives. DestroyTwitter uses a minimal amount of memory compared to its AIR-based alternatives without sacrificing functionality and performance. As a result, it can easily run in the background as an automated process.
Fantastic App. Took me a long time to find a Twitter Client that I liked. UNFORTUNATELY as of Dec 2009 development has ended. Unless someone else takes it over (the developer is not interested in releasing the code) it won't be long until other apps pass it. It's a damn shame. I loved it!
This is easily the lightest Air-powered Twitter app I have ever seen. In fact, you will not even notice it's an Air app when you use it, since it won't be using up gobs of ram, and causing stuttering and lag.
What is missing is multiple account support, but that is coming in 2.0. But I have found that it's perfect for a single personal account, while 'business' accounts are better handled by HootSuite.